Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins.

نویسندگان

  • Jason Yamaki
  • Timothy Synold
  • Annie Wong-Beringer
چکیده

Staphylococcus aureus strains (n = 50) causing complicated skin and skin structure infections produced various levels of phenol-soluble modulin alpha-type (PSMα) peptides; some produced more than twice that produced by the control strain (LAC USA300). TR-700 (oxazolidinone) and clindamycin strongly inhibited PSM production at one-half the MIC but exhibited weak to modest induction at one-fourth and one-eighth the MICs, primarily in low producers. Adequate dosing of these agents is emphasized to minimize the potential for paradoxical induction of virulence.

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عنوان ژورنال:
  • Antimicrobial agents and chemotherapy

دوره 55 9  شماره 

صفحات  -

تاریخ انتشار 2011